Collot was born in Paris in 1923. He studied viola at the Conservatoire de Paris with Maurice Vieux, chamber music with Joseph Calvet, and composition with Maurice Hewitt and Arthur Honegger.
He won first prizes in viola 1944 and chamber music 1949.
Collot has been a member of Parrenin Quartet, Radiodiffusion Française String Quartet, and Bernède Quartet.
In 1960 he founded Le Trio à Cordes Français with violinist Gérard Jarry and cellist Michel Tournus. The ensemble performed together for 32 years. From 1957 to 1986 he was Principal Violist with the Orchestra of the Paris Opera.
Collot served as Professor of Viola for twenty years (1969–1989) at the Conservatoire de Paris. Many contemporary violists have been his students: Pierre-Henri Xuereb, Jean Sulem (who succeeded him at the Conservatoire in 1989), Emile Cantor, Jacques Borsarello, Laurent Verney, Jean-Paul Minali Bella.
An exponent of contemporary music, Collot performed in Pierre Boulez’s Domaine Musical concerts until 1970 and has inspired many compositions for viola including Quatre Duos for viola and piano (1979) by Betsy Jolas and, in particular, the Sequenza VI for viola solo (1967) by Luciano Berio.
He has performed and lectured internationally and has served on juries of music competitions including those in Geneva and Munich.